Linking alpha-synuclein properties with oxidation: a hypothesis on a mechanism underling cellular aggregation.


α-Synuclein is a small, natively unstructured protein with propensity to aggregate. α-Synuclein fibrils are major components of Lewy bodies that are hallmarks of many neurodegenerative diseases. The solution properties and aggregation behavior of α-synuclein has been well characterized, but despite numerous studies that address the role of α-synuclein in… (More)
DOI: 10.1007/s10863-014-9540-5


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