Linking Stochastic Fluctuations in Chromatin Structure and Gene Expression

  title={Linking Stochastic Fluctuations in Chromatin Structure and Gene Expression},
  author={Christopher R. Brown and Changhui Mao and Elena Falkovskaia and Melissa S. Jurica and Hinrich Boeger},
  booktitle={PLoS biology},
The number of mRNA and protein molecules expressed from a single gene molecule fluctuates over time. These fluctuations have been attributed, in part, to the random transitioning of promoters between transcriptionally active and inactive states, causing transcription to occur in bursts. However, the molecular basis of transcriptional bursting remains poorly understood. By electron microscopy of single PHO5 gene molecules from yeast, we show that the "activated" promoter assumes alternative… CONTINUE READING
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