Linking RNA Sequence, Structure, and Function on Massively Parallel High-Throughput Sequencers.

@article{Denny2018LinkingRS,
  title={Linking RNA Sequence, Structure, and Function on Massively Parallel High-Throughput Sequencers.},
  author={Sarah K. Denny and William James Greenleaf},
  journal={Cold Spring Harbor perspectives in biology},
  year={2018}
}
SUMMARYHigh-throughput sequencing methods have revolutionized our ability to catalog the diversity of RNAs and RNA-protein interactions that can exist in our cells. However, the relationship between RNA sequence, structure, and function is enormously complex, demonstrating the need for methods that can provide quantitative thermodynamic and kinetic measurements of macromolecular interaction with RNA, at a scale commensurate with the sequence diversity of RNA. Here, we discuss a class of methods… 
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