Linking Hebb's coincidence-detection to memory formation.

  title={Linking Hebb's coincidence-detection to memory formation.},
  author={Joe Z. Tsien},
  journal={Current opinion in neurobiology},
  volume={10 2},
  • Joe Z. Tsien
  • Published 2000 in Current opinion in neurobiology
The theoretical foundations of learning and memory were laid by Donald Hebb 50 years ago. Recent genetic experiments that enhanced coincidence-detection of the NMDA receptor (a molecular master-switch in implementing Hebb's rule) and that led to better learning and memory in adult animals have substantially validated Hebb's rule in memory formation in the brain.