Linking Epstein-Barr virus infection to multiple sclerosis.

@article{Bordon2022LinkingEV,
  title={Linking Epstein-Barr virus infection to multiple sclerosis.},
  author={Yvonne Bordon},
  journal={Nature reviews. Immunology},
  year={2022}
}
  • Yvonne Bordon
  • Published 9 February 2022
  • Medicine
  • Nature reviews. Immunology
EBV Infection and Its Regulated Metabolic Reprogramming in Nasopharyngeal Tumorigenesis
TLDR
Based on the understanding of the host’s metabolic signaling alterations induced by EBV, a new perspective is provided on the interplay between EBV infection and these metabolic pathways and offering a potential therapeutic intervention strategy in the treatment of EBV-associated malignant diseases.

References

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Clonally Expanded B Cells in Multiple Sclerosis Bind EBV EBNA1 and GlialCAM.
TLDR
High-affinity molecular mimicry between the EBV transcription factor EBNA1 and the CNS protein GlialCAM is demonstrated, providing a mechanistic link for the association between MS and EBV, and could guide the development of novel MS therapies.
Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis
TLDR
It is determined that Epstein-Barr virus infection greatly increased the risk of subsequent multiple sclerosis and that it preceded the development of disease, supporting its potential role in the pathogenesis of multiple sclerosis.