Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson’s disease

@article{Bonifati2003LinkingDT,
  title={Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson’s disease},
  author={Vincenzo Bonifati and Ben A. Oostra and Peter Heutink},
  journal={Journal of Molecular Medicine},
  year={2003},
  volume={82},
  pages={163-174}
}
Rare monogenic forms of Parkinson’s disease (PD) are promoting our understanding of the molecular pathways involved in the common, non-Mendelian forms of the disease. Here, we focus on PARK7, an autosomal recessive form of early-onset parkinsonism caused by mutations in the DJ-1 gene. We first review the genetics of this form and the rapidly expanding knowledge about the structure and biochemical properties of the DJ-1 protein. We also discuss how DJ-1 dysfunction might lead to… Expand
DJ-1 (PARK7) and Parkinson's Disease
TLDR
This chapter reviews more recent advances in the genetic and clinical aspects of parkinson protein 7 (PARK7) and discusses the molecular biology of this form and proposes that DJ-1 influences gene expression by interacting with transcription factors. Expand
Role of DJ-1 in parkinson’s disease
TLDR
The function of DJ-1 is still unknown; however, it is associated with various cellular processes, including response to oxidative stress, cellular transformation, RNAbinding, androgen-receptor signaling, spermatogenesis, and fertilization. Expand
Role of DJ-1 in Parkinson's disease
TLDR
The function of DJ-1 is still unknown; however, it is associated with various cellular processes, including response to oxidative stress, cellular transformation, RNA-binding, androgen-receptor signaling, spermatogenesis, and fertilization. Expand
Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress.
TLDR
It is shown that pathogenic mutant forms of DJ-1 specifically but differentially associate with parkin, an E3 ubiquitin ligase, which may link DJ- 1 and parkin in a common molecular pathway at multiple levels that may have important implications for understanding the pathogenesis of inherited and sporadic PD. Expand
Understanding the molecular causes of Parkinson's disease.
TLDR
What has been learnt from the study of the principal genes of Parkinson's disease and what has been elucidated of the molecular pathways that lead to cell degeneration are discussed. Expand
DJ-1/PARK7: A New Therapeutic Target for Neurodegenerative Disorders.
TLDR
DJ-1 and DJ-1-targeting molecules/compounds will be useful therapeutic targets for various neurodegenerative disorders due to their various functions such as antioxidant capacity, chaperone function and as a proteolytic pathway. Expand
Folding, function and subcellular localization of parkin
TLDR
This study provided new insight into the propensity of parkin to misfold and suggested that pathogenic mutations can induce the formation of non-native conformers at distinct steps in the folding pathway of Parkin. Expand
The role of exogenous DJ-1 in neuroprotection
TLDR
In order to find some possible extracellular DJ-1 interactors, a pull-down assay followed by LC-MS/MS analysis was performed and allowed the identification of some interesting proteins, including cell adhesion proteins, proteins involved in cellular processes, such as, axon guidance, cell migration and proliferation, carbohydrate metabolism, synaptic process and positive or negative regulation of signalling pathways. Expand
Molecular pathophysiology of Parkinson's disease.
TLDR
Increasing evidence indicates that deficits in mitochondrial function, oxidative and nitrosative stress, the accumulation of aberrant or misfolded proteins, and ubiquitin-proteasome system dysfunction may represent the principal molecular pathways or events that commonly underlie the pathogenesis of sporadic and familial forms of PD. Expand
DJ-1 Modulates α-Synuclein Aggregation State in a Cellular Model of Oxidative Stress: Relevance for Parkinson's Disease and Involvement of HSP70
TLDR
DJ-1 inactivation may promotealpha-syn aggregation and the related toxicity, and in this model HSP70 is involved in the antioxidant response and in the regulation of alpha-syn fibril formation. Expand
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