Linker structure-activity relationships in fluorodeoxyglucose chlorambucil conjugates for tumor-targeted chemotherapy.

Abstract

Nitrogen mustards, such as chlorambucil (CLB), can cause adverse side-effects due to ubiquitous distribution in non-target organs. To minimize this toxicity, strategies of tumor-targeting drug delivery have been developed, where a cytotoxic warhead is linked to a tumor-cell-specific small ligand. Malignant cells exhibit marked glucose avidity and an… (More)
DOI: 10.1016/j.bmc.2017.08.043

Cite this paper

@article{Hilali2017LinkerSR, title={Linker structure-activity relationships in fluorodeoxyglucose chlorambucil conjugates for tumor-targeted chemotherapy.}, author={Mostafa El Hilali and Bastien Reux and Eric D{\'e}biton and Fernand Leal and M. -J. Galmier and Magali Vivier and J. M. Chezal and {\'E}lisabeth Miot-Noirault and Pascal Coudert and Valerie D Weber}, journal={Bioorganic & medicinal chemistry}, year={2017}, volume={25 20}, pages={5692-5708} }