Linker length and composition influence the flexibility of Oct-1 DNA binding.

@article{Leeuwen1997LinkerLA,
  title={Linker length and composition influence the flexibility of Oct-1 DNA binding.},
  author={Hans C van Leeuwen and M J Strating and Marije G.A. Rensen and Wouter de Laat and Peter C. van der Vliet},
  journal={The EMBO journal},
  year={1997},
  volume={16 8},
  pages={2043-53}
}
POU domain transcription factors have two separate helix-turn-helix DNA-binding subdomains, the POU homeodomain (POUhd) and the POU-specific domain (POUs). Each subdomain recognizes a specific subsite of 4 or 5 bp in the octamer recognition sequence. The Oct-1 POU subdomains are connected by a 23 amino acid unstructured linker region. To investigate the requirements for the linker and its role in DNA recognition, we constructed POU domains in which the subdomains are connected with linkers… CONTINUE READING

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