Linker insertion scanning of regA, an activator of exotoxin A production in Pseudomonas aeruginosa.

@article{Raivio1996LinkerIS,
  title={Linker insertion scanning of regA, an activator of exotoxin A production in Pseudomonas aeruginosa.},
  author={Tracy L. Raivio and Dorith Hoffer and Royal Prince and Michael Lawrence Vasil and Douglas Gordon Storey},
  journal={Molecular microbiology},
  year={1996},
  volume={22 2},
  pages={
          239-54
        }
}
RegA is a transcriptional activator that controls exotoxin A (ETA) production in Pseudomonas aeruginosa. To date, functional assays performed with the purified protein have not clearly defined the molecular mechanism of action of RegA. In this study, we sought to identify important coding regions of regA by analysing the sequences around linker insertion mutations in regA that affected toxA transcription. First, we constructed a strain with the regAB locus deleted from the chromosome, PA103… CONTINUE READING
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