Linker histones incorporation maintains chromatin fiber plasticity.


Genomic DNA in eukaryotic cells is organized in supercoiled chromatin fibers, which undergo dynamic changes during such DNA metabolic processes as transcription or replication. Indeed, DNA-translocating enzymes like polymerases produce physical constraints in vivo. We used single-molecule micromanipulation by magnetic tweezers to study the response of… (More)
DOI: 10.1016/j.bpj.2011.03.064


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