Linker histones H1 and H5 prevent the mobility of positioned nucleosomes.

@article{Pennings1994LinkerHH,
  title={Linker histones H1 and H5 prevent the mobility of positioned nucleosomes.},
  author={Steve C. Pennings and G Meersseman and E. Morton Bradbury},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 22},
  pages={
          10275-9
        }
}
We have previously identified a generally occurring short-range mobility of nucleosome cores on DNA in relatively low ionic strength conditions. Here we report that this mobility of histone octamers positioned on constructs of 5S rDNA is suppressed by the binding of histone H1 or H5 to the nucleosome. Histone H5 is the more potent inhibitor of nucleosome mobility, in accordance with its higher affinity for chromatin. We propose that this reversible restraint on chromatin dynamics may play a… CONTINUE READING

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