Linked thioredoxin-glutathione systems in platyhelminths.

  title={Linked thioredoxin-glutathione systems in platyhelminths.},
  author={Gustavo Salinas and Murray E Selkirk and Cora Chalar and Rick M. Maizels and Cecilia Fern{\'a}ndez},
  journal={Trends in parasitology},
  volume={20 7},
The thioredoxin and glutathione systems play a central role in thiol-disulfide redox homeostasis in many organisms by providing electrons to essential enzymes, and defence against oxidative stress. These systems have recently been characterized in platyhelminth parasites, and the emerging biochemical scenario is the existence of linked processes with the enzyme thioredoxin glutathione reductase supplying reducing equivalents to both pathways. In contrast to their hosts, conventional thioredoxin… CONTINUE READING