Linked activation of nitric oxide synthase and cyclooxygenase in peripheral monocytes of asymptomatic migraine without aura patients.

@article{Stirparo2000LinkedAO,
  title={Linked activation of nitric oxide synthase and cyclooxygenase in peripheral monocytes of asymptomatic migraine without aura patients.},
  author={Giuseppe Stirparo and Alessandra Zicari and Mara Favilla and Marcella Lipari and Paolo Martelletti},
  journal={Cephalalgia : an international journal of headache},
  year={2000},
  volume={20 2},
  pages={100-6}
}
Many reports indicate that nitric oxide (NO) could be involved in migraine without aura (MWA), an extremely diffuse clinical event. Since monocyte may be a relevant source of NO, we analysed monocyte activation in MWA patients, in a period in which they were free of symptoms. NO basal production by MWA peripheral monocytes was significantly higher than in healthy subjects (91.25+/-8.6 microM/10(6) cells vs. 22.6+/-3.2 microM/106 cells). Interestingly, even the release of prostaglandin E2 (PGE2… CONTINUE READING

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