Linkage studies of X-linked mental retardation: High frequency of recombination in the telomeric region of the human X chromosome (fragile site/linkage/recombination/X chromosome)

@article{Davies1985LinkageSO,
  title={Linkage studies of X-linked mental retardation: High frequency of recombination in the telomeric region of the human X chromosome (fragile site/linkage/recombination/X chromosome)},
  author={K. Davies and M. G. Matt{\'e}i and J. F. Mattei and H. Veenema and S A McGlade and Katherine Harper and Niels Tommerup and K Niels{\'e}n and Margareta Mikkelsen and Peter Beighton and Dennis Drayna and R. Senior White and Marcus E. Pembrey},
  journal={Human Genetics},
  year={1985},
  volume={70},
  pages={249-255}
}
SummaryOne of the commonest forms of X-linked mental retardation is associated with a fragile site at Xq27 on the human X chromosome which can be visualised structurally after culturing cells in folate-deficient media. Unusually, the mutation can be transmitted through a phenotypically normal male. There is already some evidence that the gene loci for G6PD and factor IX are linked to this mental retardation locus. We have followed the inheritance of a DNA sequence 52A, in fragile site families… CONTINUE READING

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The role of recombination in the evolvement of the fragile X mutation

  • Human Genetics
  • 1989
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Linkage heterogeneity and fragile X

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Multilocus analysis of the fragile X syndrome

  • Human Genetics
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