Linkage strategies for genetically complex traits. II. The power of affected relative pairs.

@article{Risch1990LinkageSF,
  title={Linkage strategies for genetically complex traits. II. The power of affected relative pairs.},
  author={Neil J. Risch},
  journal={American journal of human genetics},
  year={1990},
  volume={46 2},
  pages={229-41}
}
  • Neil J. Risch
  • Published 1990 in American journal of human genetics
The power to detect disease-susceptibility loci through linkage analysis using pairs of affected relatives and affected-unaffected pairs is examined. Allelic identity by descent (ibd) for a completely polymorphic marker for sibling, uncle-nephew, grandparent-grandchild, half-sib, and first-cousin pairs is considered. Affected-unaffected pairs generally represent a poor strategy. For single-locus models, ibd depends on lambda R, the risk ratio for type R relatives compared with population… CONTINUE READING
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