Linkage-specific conformational ensembles of non-canonical polyubiquitin chains.

  title={Linkage-specific conformational ensembles of non-canonical polyubiquitin chains.},
  author={Carlos A. Casta{\~n}eda and Apurva Chaturvedi and Christina M. Camara and Joseph E. Curtis and Susan Krueger and David Fushman},
  journal={Physical chemistry chemical physics : PCCP},
  volume={18 8},
Polyubiquitination is a critical protein post-translational modification involved in a variety of processes in eukaryotic cells. The molecular basis for selective recognition of the polyubiquitin signals by cellular receptors is determined by the conformations polyubiquitin chains adopt; this has been demonstrated for K48- and K63-linked chains. Recent studies of the so-called non-canonical chains (linked via K6, K11, K27, K29, or K33) suggest they play important regulatory roles in growth… 

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