Linkage relationships between a major gene for catechol-o-methyltransferase activity and 25 polymorphic marker systems.

@article{Wilson1984LinkageRB,
  title={Linkage relationships between a major gene for catechol-o-methyltransferase activity and 25 polymorphic marker systems.},
  author={Alexander F. Wilson and Robert C. Elston and Roger M. Siervogel and Richard L. Weinshilboum and L. J. Ward},
  journal={American journal of medical genetics},
  year={1984},
  volume={19 3},
  pages={
          525-32
        }
}
Segregation analysis has provided evidence suggesting the existence of a major gene for catechol-o-methyltransferase (COMT) activity in man. Five large families (4 Caucasian, 1 black), with a total of 1,189 individuals, were ascertained as part of a genetic study of blood pressure. Erythrocyte COMT activity and status at 25 polymorphic genetic marker loci were determined on more than 518 individuals in these pedigrees. Genetic linkage analysis of COMT with each of the 25 marker loci was… CONTINUE READING
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