Linkage of the gene for an autosomal dominant form of juvenile amyotrophic lateral sclerosis to chromosome 9q34.

@article{Chance1998LinkageOT,
  title={Linkage of the gene for an autosomal dominant form of juvenile amyotrophic lateral sclerosis to chromosome 9q34.},
  author={Phillip F. Chance and Bruce A. Rabin and Stephen G. Ryan and Yan Ding and Mena T Scavina and Barbara J. Crain and John Wesley Griffin and David Reid Cornblath},
  journal={American journal of human genetics},
  year={1998},
  volume={62 3},
  pages={633-40}
}
We performed genetic mapping studies of an 11-generation pedigree with an autosomal dominant, juvenile-onset motor-systems disease. The disorder is characterized by slow progression, distal limb amyotrophy, and pyramidal tract signs associated with severe loss of motor neurons in the brain stem and spinal cord. The gene for this disorder, classified as a form of juvenile amyotrophic lateral sclerosis (ALS), is designated "ALS4." We performed a genomewide search and detected strong evidence for… CONTINUE READING
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Linkage of recessive familial amyotrophic lateral sclerosis to chromosome 2 q 33 - 35

  • A Hentati, K Bejaoui, +4 authors DA Figelwicz
  • Nat Genet
  • 1994
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