Linkage of the four gamma subclass heavy chain genes.

  title={Linkage of the four gamma subclass heavy chain genes.},
  author={William Roeder and Richard Maki and Andr{\'e} Traunecker and Susumu Tonegawa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={78 1},
The genes for the heavy-chain constant regions of the four gamma subclass immunoglobulins were identified in a set of overlapping mouse DNA fragments representing about 100 kilobase pairs (kb) of the mouse genome that was cloned from bacteriophage lambda libraries of BALB/c mouse embryo DNA. R-loop mapping studies show that the genes are located 5'-C gamma 3-34 kb-C gamma 1-21 kb-C gamma 2b-15 kb-C gamma 2a-3' and lie in the same transcriptional orientation. Two DNA segments, one of 19 kb and… CONTINUE READING
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