Linkage of the dopamine D4 receptor gene and attention-deficit/hyperactivity disorder.

@article{Sunohara2000LinkageOT,
  title={Linkage of the dopamine D4 receptor gene and attention-deficit/hyperactivity disorder.},
  author={Glen A Sunohara and Wendy Roberts and Molly M. Malone and Russell J. Schachar and Rosemary Tannock and V S Basile and Tim L. Wigal and Sharon B. Wigal and Sabrina Schuck and J. J. Moriarty and James M. Swanson and James L Kennedy and Cathy L. Barr},
  journal={Journal of the American Academy of Child and Adolescent Psychiatry},
  year={2000},
  volume={39 12},
  pages={1537-42}
}
OBJECTIVE There is considerable evidence supporting a genetic component in the etiology of attention-deficit/hyperactivity disorder (ADHD). Because stimulant medications act primarily on the dopaminergic system, dopamine system genes are prime candidates for genetic susceptibility factors for ADHD. Previous studies by several groups have observed a significant association of ADHD and an allele with 7 copies of the 48 base pair repeat in the third exon of the dopamine D4 receptor. METHOD The… CONTINUE READING