Linkage of the apo CIII microsatellite with isolated low high-density lipoprotein cholesterol

@article{Devlin1998LinkageOT,
  title={Linkage of the apo CIII microsatellite with isolated low high-density lipoprotein cholesterol},
  author={Cecilia M. Devlin and Valerie L. Prenger and Michael V. Miller},
  journal={Human Genetics},
  year={1998},
  volume={102},
  pages={273-281}
}
To evaluate whether a highly polymorphic mic-rosatellite region within intron 3 of the apolipoprotein (apo) CIII gene is linked to the isolated low HDL-C phenotype, we studied eight unrelated probands (mean HDL-C=10 ±5mg/dl) and 157 biological family members. After PCR amplification of genomic DNA and denaturing polyacrylamide gel electrophoresis, 26 alleles were identified in this microsatellite including 9 alleles heretofore unreported. Quantitative sib-pair linkage analysis demonstrated… CONTINUE READING

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