Linkage of the CCR5 Delta 32 mutation with a functional polymorphism of CD45RA.

@article{Liao2000LinkageOT,
  title={Linkage of the CCR5 Delta 32 mutation with a functional polymorphism of CD45RA.},
  author={H. X. Liao and David C. Montefiori and Dhavalkumar D. Patel and David C. M. Lee and William K. Scott and Margaret A. Pericak-Vance and Barton F Haynes},
  journal={Journal of immunology},
  year={2000},
  volume={165 1},
  pages={148-57}
}
A 32-bp deletion in CCR5 (CCR5 Delta 32) confers to PBMC resistance to HIV-1 isolates that use CCR5 as a coreceptor. To study this mutation in T cell development, we have screened 571 human thymus tissues for the mutation. We identified 72 thymuses (12.6%) that were heterozygous and 2 (0.35%) that were homozygous for the CCR5 Delta 32 mutation. We found that thymocyte development was normal in both CCR5 Delta 32 heterozygous and homozygous thymuses. In 3% of thymuses we identified a functional… CONTINUE READING