Linkage of 'pure' autosomal recessive familial spastic paraplegia to chromosome 8 markers and evidence of genetic locus heterogeneity.

Abstract

'Pure' familial spastic paraplegias (FSP) are neurodegenerative disorders that are clinically characterized by progressive spasticity of the lower limbs and are inherited as autosomal dominant (DFSP) or autosomal recessive (RFSP) traits. The primary defect in FSP is unknown. Genetic linkage analysis was applied to five RFSP families from Tunisia. In four of… (More)

Topics

Cite this paper

@article{Hentati1994LinkageO, title={Linkage of 'pure' autosomal recessive familial spastic paraplegia to chromosome 8 markers and evidence of genetic locus heterogeneity.}, author={Asma Hentati and Margaret A. Pericak-Vance and W Y Hung and Samir Belal and Nigel G Laing and Rose Mary Boustany and Fayçal Hentati and Myriam Ben Hamida and Teepu Siddique}, journal={Human molecular genetics}, year={1994}, volume={3 8}, pages={1263-7} }