Linkage of leprosy susceptibility to Parkinson's disease genes.

  title={Linkage of leprosy susceptibility to Parkinson's disease genes.},
  author={Ellen Buschman and Emil Skamene},
  journal={International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association},
  volume={72 2},
  • E. BuschmanE. Skamene
  • Published 1 June 2004
  • Biology, Medicine
  • International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
In early 2003, an international team of scientists conducted a genome scan in Vietnamese multiplex leprosy families and found that susceptibility to leprosy was significantly linked to region q25 on the long arm of chromosome 6. Further confirmation of the chromosome 6 locus was provided by high-resolution linkage mapping in simplex leprosy families. Now, in a continuation of these findings, the team has pinpointed the chromosome 6 susceptibility locus to the 5' regulatory promoter region… 

Treatment of leprosy/Hansen's disease in the early 21st century

  • S. Worobec
  • Medicine, Biology
    Dermatologic therapy
  • 2009
Hansen's disease is a worldwide disease with about 150 new cases reported annually in the United States, and many patients experience severe reversal and erythema nodosum leprosum reactions that also require treatment.

The Continuing Challenges of Leprosy

This review focuses on recent advances in the understanding of M. leprae and the host response to it, especially concerning molecular identification of M.'s genome, transcriptome, and proteome, its mechanisms of microbial resistance, and recognition of strains by variable-number tandem repeat analysis.

Leprosy: A Time for Elimination by 2020

This review summarizes the disease, efficacy of treatment, and elucidates current policies of the WHO in the task to eliminate leprosy.

Molluscum-like Lesions in a 12-Year-Old Boy: Answer

Clinically, localized lesions with sensory loss in association to local nerve enlargement are most specific, the gold standard for diagnosis is the visualization of M. leprae bacilli on H&E and Fite stains.

Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures

It is reported that full-length Lrrk2 is a relatively common constituent of human peripheral blood mononuclear cells (PBMC) including affinity isolated, CD14+ monocytes, CD19+ B cells, and CD4+ as well as CD8+ T cells and speculated that the role of LRRK2 in immune cells may also be relevant to the susceptibility of developing PD or its progression.

Exploring the Role of Parkinson’s-Linked Leucine-Rich Repeat Kinase-2 in the Immune System

Using nanofiltration membranes for the recovery of phosphorous with a second type of technology for the Recovery of nitrogen is suggest to be a viable process.

Low prevalence of most frequent pathogenic variants of six PARK genes in sporadic Parkinson's disease.

The study suggests that the heterozygous deletion of exon 2 in the PARK2 gene is a risk factor for EOPD, and novel population-specific variants may underlie PD susceptibility in Mexican mestizos.

Infectious basis to the pathogenesis of Parkinson's disease.



Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population

A genome-wide search for loci controlling susceptibility to leprosy per se is reported here on in a panel of 86 families including 205 siblings affected with leproSy from Southern Vietnam, finding significant evidence for a susceptibility gene on chromosome region 6q25.

Susceptibility to leprosy is associated with PARK2 and PACRG

Variants in the regulatory region shared by PARK2 and PACRG act as common risk factors for leprosy by using a systematic association scan of the chromosomal interval most likely to harbour this leproSy susceptibility locus.

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Mutations in the newly identified gene appear to be responsible for the pathogenesis of Autosomal recessive juvenile parkinsonism, and the protein product is named ‘Parkin’.

Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones.

Functional subsets of human T cells were delineated by analyzing patterns of lymphokines produced by clones from individuals with leprosy and by T cell clones of known function, and interleukin-4 was found to be necessary for suppression in vitro.