Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal.

@article{Salzano2014LinkageOI,
  title={Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal.},
  author={Sonia Salzano and Paola Checconi and Eva-Maria Hanschmann and Christopher Horst Lillig and Lucas D. Bowler and Philippe Chan and David Vaudry and Manuela Mengozzi and Lucia Coppo and Sandra M. Sacre and Kondala R Atkuri and Bita Sahaf and Leonard A. Herzenberg and Leonore Herzenberg and Lisa M. Mullen and Pietro Ghezzi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 33},
  pages={12157-62}
}
The mechanism by which oxidative stress induces inflammation and vice versa is unclear but is of great importance, being apparently linked to many chronic inflammatory diseases. We show here that inflammatory stimuli induce release of oxidized peroxiredoxin-2 (PRDX2), a ubiquitous redox-active intracellular enzyme. Once released, the extracellular PRDX2 acts as a redox-dependent inflammatory mediator, triggering macrophages to produce and release TNF-α. The oxidative coupling of glutathione… CONTINUE READING
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