Linkage of a cardiac arrhythmia, the long QT syndrome, and the Harvey ras-1 gene.

@article{Keating1991LinkageOA,
  title={Linkage of a cardiac arrhythmia, the long QT syndrome, and the Harvey ras-1 gene.},
  author={Mark Taylor Keating and Donald L. Atkinson and Christine K Dunn and Katherine W. Timothy and G. Michael Vincent and M. Leppert},
  journal={Science},
  year={1991},
  volume={252 5006},
  pages={
          704-6
        }
}
Genetic factors contribute to heart disease. In this study, linkage analyses have been performed in a family that is predisposed to sudden death from cardiac arrhythmias, the long QT syndrome (LQT). A DNA marker at the Harvey ras-1 locus (H-ras-1) was linked to LQT with a logarithm of the likelihood ratio for linkage (lod score) of 16.44 at theta = 0, which confirms the genetic basis of this trait and localizes this gene to the short arm of chromosome 11. As no recombination was observed… CONTINUE READING
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