Linkage of a candidate gene locus to familial combined hyperlipidemia: lecithin:cholesterol acyltransferase on 16q.

@article{Aouizerat1999LinkageOA,
  title={Linkage of a candidate gene locus to familial combined hyperlipidemia: lecithin:cholesterol acyltransferase on 16q.},
  author={Bradley E. Aouizerat and Hooman Allayee and Rita M. Cantor and Geesje M. Dallinga-Thie and Craig Lanning and Tjerk W. A. de Bruin and Aldons J. Lusis and Jerome I. Rotter},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1999},
  volume={19 11},
  pages={2730-6}
}
Familial combined hyperlipidemia (FCHL) is a common lipid disorder characterized by elevated levels of plasma cholesterol and triglycerides that is present in 10% to 20% of patients with premature coronary artery disease. To study the pathophysiological basis and genetics of FCHL, we previously reported recruitment of 18 large families. We now report linkage studies of 14 candidate genes selected for their potential involvement in the aspects of lipid and lipoprotein metabolism that are altered… CONTINUE READING

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