Linkage of Rieger syndrome to the region of the epidermal growth factor gene on chromosome 4

  title={Linkage of Rieger syndrome to the region of the epidermal growth factor gene on chromosome 4},
  author={J. Murray and S. R. Bennett and A. Kwitek and K. Small and A. Schinzel and W. Alward and J. Weber and G. Bell and K. Buetow},
  journal={Nature Genetics},
  • J. Murray, S. R. Bennett, +6 authors K. Buetow
  • Published 1992
  • Biology, Medicine
  • Nature Genetics
  • Rieger syndrome is an autosomal dominant disorder of morphogenesis in which previous cytogenetic arrangements have suggested chromosome 4 as a candidate chromosome. Using a group of highly polymorphic short tandem repeat polymorphisms (STRP), including a new tetranucleotide repeat for epidermal growth factor (EGF), significant linkage of Rieger syndrome to 4q markers has been identified. Tight linkage to EGF supports its role as a candidate gene, although a recombinant in an unaffected… CONTINUE READING
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