Linkage of IL-6 with neutrophil chemoattractant expression in virus-induced ocular inflammation.

@article{Fenton2002LinkageOI,
  title={Linkage of IL-6 with neutrophil chemoattractant expression in virus-induced ocular inflammation.},
  author={Robin R Fenton and Sara J Molesworth-Kenyon and John E. Oakes and Robert N. Lausch},
  journal={Investigative ophthalmology & visual science},
  year={2002},
  volume={43 3},
  pages={737-43}
}
PURPOSE Herpes simplex virus (HSV)-1 infection of the murine cornea is known to stimulate a vigorous interleukin (IL)-6 response, but whether this pleiotropic cytokine is an essential participant in corneal inflammation is unclear. This study was designed to compare the early inflammatory response in IL-6 gene-deficient mice to that in wild-type hosts. METHODS Gene knockout and wild-type mice (C57BL/6 background) were infected intracorneally with HSV-1 (strain RE) and observed through… CONTINUE READING

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