Linkage of 11β-hydroxylase mutations with altered steroid biosynthesis and blood pressure in the Dahl rat

@article{Cicila1993LinkageO1,
  title={Linkage of 11β-hydroxylase mutations with altered steroid biosynthesis and blood pressure in the Dahl rat},
  author={George T. Cicila and John P. Rapp and Jia-ming Wang and Elizabeth M. St. Lezin and Shi Chung Ng and Theodore W Kurtz},
  journal={Nature Genetics},
  year={1993},
  volume={3},
  pages={346-353}
}
In Dahl salt-hypertension sensitive (S) and resistant (R) strains fed a high NaCI diet, 11β-hydroxylase polymorphisms cosegregate with the adrenal capacity to synthesize 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) and blood pressure. The R rat carries an 11β-hydroxylase allele that: (i) differs from those of 12 other rat strains; (ii) is associated with a uniquely reduced capacity to synthesize 18-OH-DOC; and (iii) encodes 5 amino acid substitutions in the 11β-hydroxylase protein. The robust… CONTINUE READING
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