Linkage mapping in experimental crosses: the robustness of single-gene models.

@article{Wright1997LinkageMI,
  title={Linkage mapping in experimental crosses: the robustness of single-gene models.},
  author={Fred A. Wright and Augustine Kong},
  journal={Genetics},
  year={1997},
  volume={146 1},
  pages={417-25}
}
The robustness of parametric linkage mapping against model misspecification is considered in experimental breeding designs, with a focus on localization of the gene. By examining the expected LOD across the genome, it is shown that single-gene models are quite robust, even for polygenic traits. However, when the marker map is of low resolution, linked polygenes can give rise to an apparent "ghost" gene, mapped to an incorrect interval. The results apply equally well to quantitative traits or… CONTINUE READING

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