Linkage map of three HLA-DR beta-chain genes: evidence for a recent duplication event.

  title={Linkage map of three HLA-DR beta-chain genes: evidence for a recent duplication event.},
  author={Pierre Rollini and Bernard Mach and Jack Gorski},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={82 21},
  • P. Rollini, B. Mach, J. Gorski
  • Published 1985
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
The predominant class II, or Ia, antigen of the human major histocompatibility complex is HLA-DR. It consists of an alpha and a beta chain, the latter being responsible for the remarkable polymorphism of these Ia antigens. Studies with cloned genes had shown the existence of more than one DR beta-chain locus. We have isolated about 100 kilobases of the HLA-DR beta-chain gene region from a cosmid library generated from a consanguineous homozygous B-cell line of the DR3 haplotype. Three HLA-DR… Expand
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