Linkage information content of polymorphic genetic markers.

@article{Guo1999LinkageIC,
  title={Linkage information content of polymorphic genetic markers.},
  author={X W Guo and Robert C. Elston},
  journal={Human heredity},
  year={1999},
  volume={49 2},
  pages={112-8}
}
The Polymorphism Information Content (PIC) value is often used to measure the informativeness of a genetic marker for linkage studies. The PIC value was first derived for the case of a rare dominant disease, when one of the parents is affected, and is a function of the particular mode of disease inheritance. We first generalize the definition of the PIC value in such a way that it does not depend on the mode of inheritance of the trait being studied, and then develop a Linkage Information… CONTINUE READING

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