Linkage disequilibrium pattern and age-at-diagnosis are critical for replicating genetic associations across ethnic groups in leprosy

@article{Alter2012LinkageDP,
  title={Linkage disequilibrium pattern and age-at-diagnosis are critical for replicating genetic associations across ethnic groups in leprosy},
  author={A. J. Alter and Vinicius M Fava and Nguyen Thi Thu Huong and Meenakshi Singh and Marianna Orlova and Nguyen Van Thuc and Kiran Katoch and Vu Hong Thai and Nguyen Ngoc Ba and Laurent Abel and Narinder K Mehra and Alexandre Alca{\"i}s and Erwin Schurr},
  journal={Human Genetics},
  year={2012},
  volume={132},
  pages={107-116}
}
One of the persistent challenges of genetic association studies is the replication of genetic marker-disease associations across ethnic groups. Here, we conducted high-density association mapping of PARK2/PACRG SNPs with leprosy and identified 69 SNPs significantly associated with leprosy in 198 single-case Vietnamese leprosy families. A total of 56 associated SNPs localized to the overlapping promoter regions of PARK2/PACRG. For this region, multivariate analysis identified four SNPs belonging… CONTINUE READING

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