Linkage disequilibrium maps and disease-association mapping.

  title={Linkage disequilibrium maps and disease-association mapping.},
  author={Nikolas Maniatis},
  journal={Methods in molecular biology},
Over the last few years, association mapping of disease genes has developed into one of the most dynamic research areas of human genetics. It focuses on identifying functional polymorphisms that predispose to complex diseases. Population-based approaches are concerned with exploiting linkage disequilibrium (LD) between single-nucleotide polymorphism (SNPs) and disease-predisposing loci. The utility of SNPs in association mapping is now well established and the interest in this field has been… CONTINUE READING