Linkage disequilibrium mapping via cladistic analysis of single-nucleotide polymorphism haplotypes.

@article{Durrant2004LinkageDM,
  title={Linkage disequilibrium mapping via cladistic analysis of single-nucleotide polymorphism haplotypes.},
  author={Caroline Durrant and Krina T Zondervan and Lon R. Cardon and Sarah Hunt and Panagiotis Deloukas and Andrew P. Morris},
  journal={American journal of human genetics},
  year={2004},
  volume={75 1},
  pages={35-43}
}
We present a novel approach to disease-gene mapping via cladistic analysis of single-nucleotide polymorphism (SNP) haplotypes obtained from large-scale, population-based association studies, applicable to whole-genome screens, candidate-gene studies, or fine-scale mapping. Clades of haplotypes are tested for association with disease, exploiting the expected similarity of chromosomes with recent shared ancestry in the region flanking the disease gene. The method is developed in a logistic… CONTINUE READING
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