Linkage disequilibrium between GABRB3 gene and nonsyndromic familial cleft lip with or without cleft palate

@article{Scapoli2001LinkageDB,
  title={Linkage disequilibrium between GABRB3 gene and nonsyndromic familial cleft lip with or without cleft palate},
  author={Luca Scapoli and Marcella Martinelli and Furio Pezzetti and Francesco Carinci and M. Wernli. E. Bodo and Mauro Tognon and Paolo Carinci},
  journal={Human Genetics},
  year={2001},
  volume={110},
  pages={15-20}
}
Abstract. The malformation of nonsyndromic cleft lip with or without cleft palate (CL/P) is a common congenital disease that affects approximately 1/1000 newborns in Caucasian populations. Genetic studies indicate that CL/P has the characteristics of a complex genetic trait. Linkage analysis and mouse-model knockout studies have suggested several candidate genes mapping in different chromosome regions for CL/P malformation. On these grounds, we have investigated, by linkage disequilibrium (LD… CONTINUE READING
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Citations

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Association of the GABRB3 gene with nonsyndromic oral clefts.

  • The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
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Testing reported associations of genetic risk factors for oral clefts in a large Irish study population.

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