Linkage disequilibrium as a tool for detecting signatures of natural selection.

@article{Ennis2007LinkageDA,
  title={Linkage disequilibrium as a tool for detecting signatures of natural selection.},
  author={Sarah Ennis},
  journal={Methods in molecular biology},
  year={2007},
  volume={376},
  pages={
          59-70
        }
}
Natural selection has been theoretically and empirically proven to alter patterns of linkage disequilibrium (LD). Reciprocally, recombination, the driving force behind LD, modifies the signature of natural selection by reintroducing variation in a punctuate manner across the genome. To date, efforts to identify genes that have been subjected to historical selective pressure by examining polymorphic variation and allelic association have frequently fallen short of unambiguously distinguishing… CONTINUE READING

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