Linkage disequilibrium and demographic history of the isolated population of the Faroe Islands

@article{Jorgensen2002LinkageDA,
  title={Linkage disequilibrium and demographic history of the isolated population of the Faroe Islands},
  author={Tove Hedegaard Jorgensen and Birte Degn and August G. Wang and Maria Vang and Hugh M.D. Gurling and Gursharan Kalsi and Andrew McQuillin and Torben Arvid Kruse and Ole Mors and Henrik Ewald},
  journal={European Journal of Human Genetics},
  year={2002},
  volume={10},
  pages={381-387}
}
The isolated population of the Faroe Islands has a history of recent expansion after being limited to a small size for centuries. Such an isolated population may be ideal for linkage disequilibrium mapping of disease genes if linkage disequilibrium (LD) extends over large regions. Analyses of 18 markers on 12q24.3, spanning a region of 4.3 Mb (16 cM), revealed extensive LD in the Faroese population. Maximum LD was found between marker pairs separated by more than 3.8 Mb. The same region had a… CONTINUE READING