Linkage disequilibrium analysis of childhood-onset spinal muscular atrophy (SMA) in the French-Canadian population.

@article{Simard1994LinkageDA,
  title={Linkage disequilibrium analysis of childhood-onset spinal muscular atrophy (SMA) in the French-Canadian population.},
  author={Louise R. Simard and Gary Prescott and Camille Rochette and Kenneth Morgan and Bertrand Lemieux and Jean Mathieu and Serge B. Melançon and Michel Vanasse},
  journal={Human molecular genetics},
  year={1994},
  volume={3 3},
  pages={459-63}
}
Spinal muscular atrophy (SMA) is, after Duchenne muscular dystrophy, the most common neuromuscular disorder in childhood. The gene responsible for childhood SMA has been mapped to the q11.2-q13.3 region of chromosome 5. We have extended our linkage studies of SMA in the French-Canadian population to include microsatellite markers at the D5S125, D5S351, D5S435, JK53CA1/2 and MAP1B loci. These markers span about 4 cM of the SMA candidate region. We observed significant evidence for linkage… CONTINUE READING
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