Linkage disequilibrium across six prion gene regions spanning 20 kbp in U.S. sheep

@article{Green2006LinkageDA,
  title={Linkage disequilibrium across six prion gene regions spanning 20 kbp in U.S. sheep},
  author={Benedict T. Green and Michael P Heaton and Michael L. Clawson and William W. Laegreid},
  journal={Mammalian Genome},
  year={2006},
  volume={17},
  pages={1121-1129}
}
Single nucleotide polymorphisms (SNPs) and haplotype alleles within the prion gene (PRNP) coding sequence of domestic sheep (Ovis aries) are associated with genetic predisposition to scrapie, a transmissible spongiform encephalopathy disease of sheep. This report describes regions of linkage disequilibrium (LD) throughout the PRNP gene region in U.S. sheep and provides a genetic framework for identifying additional PRNP determinants associated with scrapie resistance. Four sequence tagged sites… CONTINUE READING

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