Linkage between tyrosine hydroxylase gene and affective disorder cannot be excluded in two of six pedigrees.

Abstract

Genetic linkage between manic depression and DNA markers on the short arm of chromosome 11 was first reported in 1987 but not supported by further analyses. However, genetic markers at the tyrosine hydroxylase (TH) gene located within this region have been reported to show allelic association with the affective disorder phenotype. We present the results of… (More)

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