Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase.

@article{Kanjee2011LinkageBT,
  title={Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase.},
  author={Usheer Kanjee and Irina Gutsche and Eftichia Alexopoulos and Boyu Zhao and Majida El Bakkouri and Guillaume Thibault and Kaiyin Liu and Shaliny Ramachandran and Jamie D. Snider and Emil F. Pai and Walid A. Houry},
  journal={The EMBO journal},
  year={2011},
  volume={30 5},
  pages={931-44}
}
The Escherichia coli inducible lysine decarboxylase, LdcI/CadA, together with the inner-membrane lysine-cadaverine antiporter, CadB, provide cells with protection against mild acidic conditions (pH∼5). To gain a better understanding of the molecular processes underlying the acid stress response, the X-ray crystal structure of LdcI was determined. The structure revealed that the protein is an oligomer of five dimers that associate to form a decamer. Surprisingly, LdcI was found to co-crystallize… CONTINUE READING

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