Linkage between rheumatoid arthritis susceptibility and the presence of HLA-DR4 and DR beta allelic third hypervariable region sequences in southern Chinese persons.

@article{Seglias1992LinkageBR,
  title={Linkage between rheumatoid arthritis susceptibility and the presence of HLA-DR4 and DR beta allelic third hypervariable region sequences in southern Chinese persons.},
  author={J Seglias and Edmund Kwok-Ming Li and Michael G. Cohen and Raymond Woon Sing Wong and Paul Keith Potter and Alex K So},
  journal={Arthritis and rheumatism},
  year={1992},
  volume={35 2},
  pages={163-7}
}
OBJECTIVE To analyze HLA-DR and DQ associations with rheumatoid arthritis (RA) in patients from southern China. METHODS In 66 patients and 45 controls, restriction fragment length polymorphism studies were performed using DRB, DQA, and DQB probes, and DRB allele-specific typing of polymerase chain reaction-amplified DRB DNA: RESULTS The frequency of HLA-DR4 was significantly increased among RA patients (42.4% versus 17.8%). Increased frequencies of the DQA3 allele (77.8% versus 48.9%) and… CONTINUE READING