Linkage between reovirus-induced apoptosis and inhibition of cellular DNA synthesis: role of the S1 and M2 genes.

@article{Tyler1996LinkageBR,
  title={Linkage between reovirus-induced apoptosis and inhibition of cellular DNA synthesis: role of the S1 and M2 genes.},
  author={Kenneth L Tyler and Margaret Squier and Abigail L Brown and Brigid Pike and Dean Willis and Stephanie M Oberhaus and Terence S Dermody and J. John Cohen},
  journal={Journal of virology},
  year={1996},
  volume={70 11},
  pages={
          7984-91
        }
}
The mammalian reoviruses are capable of inhibiting cellular DNA synthesis and inducing apoptosis. Reovirus strains type 3 Abney (T3A) and type 3 Dearing (T3D) inhibit cellular DNA synthesis and induce apoptosis to a substantially greater extent than strain type 1 Lang (T1L). We used T1L x T3A and T1L x T3D reassortant viruses to identify viral genes associated with differences in the capacities of reovirus strains to elicit these cellular responses to viral infection. We found that the S1 and… CONTINUE READING

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