Linkage between oligomerization and DNA binding in Drosophila doublesex proteins.

@article{Cho1998LinkageBO,
  title={Linkage between oligomerization and DNA binding in Drosophila doublesex proteins.},
  author={S S Cho and Pieter C. Wensink},
  journal={Biochemistry},
  year={1998},
  volume={37 32},
  pages={11301-8}
}
The doublesex gene of Drosophila melanogaster encodes DSXM protein in males and DSXF protein in females. Dimers of each protein bind a DNA site from which DSXM represses and DSXF activates transcription. Amino acids 1-397 are identical between the proteins and include a domain (DBD) for both DNA binding and protein oligomerization. The remaining nonhomologous and therefore sex-specific C-termini include an essential part of a second oligomerization domain. We have used mobility shift assays to… CONTINUE READING