Linkage between male infertility and trinucleotide repeat expansion in the androgen-receptor gene

  title={Linkage between male infertility and trinucleotide repeat expansion in the androgen-receptor gene},
  author={A. Dowsing and El Yong and M. Clark and R. McLachlan and A. Trounson},
  journal={The Lancet},
  • A. Dowsing, El Yong, +2 authors A. Trounson
  • Published 1999
  • Biology, Medicine
  • The Lancet
  • BACKGROUND Androgens acting via the androgen receptor bring about stimulation and maintenance of spermatogenesis. If mutations in the androgen-receptor gene interfere with the receptor's function, this effect may partly account for impaired spermatogenesis. We aimed to find out whether expansion of a trinucleotide repeat in the androgen-receptor gene is associated with male infertility. METHODS We analysed 67 coded semen and blood samples from a predominantly white group of male infertility… CONTINUE READING
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