Linkage and potential association of obesity-related phenotypes with two genes on chromosome 12q24 in a female dizygous twin cohort

@article{Wilson2006LinkageAP,
  title={Linkage and potential association of obesity-related phenotypes with two genes on chromosome 12q24 in a female dizygous twin cohort},
  author={Scott G. Wilson and Gail Dodge Ian Balitsky Charles I. Sukenik John Adam and Maria L. Langdown and Rikard Reneland and Andreas Braun and Toby Andrew and Gabriela L. Surdulescu and Maria Norberg and Frank Dudbridge and Peter W. Reed and Philip N. Sambrook and Patrick W. Kleyn and Tim D. Spector},
  journal={European Journal of Human Genetics},
  year={2006},
  volume={14},
  pages={340-348}
}
Obesity is a multifactorial disorder with a complex phenotype. It is a significant risk factor for diabetes and hypertension. We assessed obesity-related traits in a large cohort of twins and performed a genome-wide linkage scan and positional candidate analysis to identify genes that play a role in regulating fat mass and distribution in women. Dizygous female twin pairs from 1094 pedigrees were studied (mean age 47.0±11.5 years (range 18–79 years)). Nonparametric multipoint linkage analyses… CONTINUE READING

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