Linkage and association between distinct variants of the APOA1/C3/A4/A5 gene cluster and familial combined hyperlipidemia.

@article{EichenbaumVoline2004LinkageAA,
  title={Linkage and association between distinct variants of the APOA1/C3/A4/A5 gene cluster and familial combined hyperlipidemia.},
  author={Sophie Eichenbaum-Voline and Michael Olivier and Emma Jones and Rossitza P. Naoumova and Bronwen Jones and Brian C Gau and Hetal N. Patel and Mary Seed and David John Betteridge and D. J. Galton and Edward M. Rubin and James M Scott and Carol C. Shoulders and Len A. Pennacchio},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2004},
  volume={24 1},
  pages={
          167-74
        }
}
OBJECTIVE Combined hyperlipidemia is a common disorder, characterized by a highly atherogenic lipoprotein profile and a substantially increased risk of coronary heart disease. The purpose of this study was to establish whether variations of apolipoprotein A5 (APOA5), a newly discovered gene of lipid metabolism located 30 kbp downstream of the APOA1/C3/A4 gene cluster, contributes to the transmission of familial combined hyperlipidemia (FCHL). METHODS AND RESULTS We performed linkage and… CONTINUE READING