Linkage and association between Plasmodium falciparum blood infection levels and chromosome 5q31–q33

@article{Flori2003LinkageAA,
  title={Linkage and association between Plasmodium falciparum blood infection levels and chromosome 5q31–q33},
  author={Laurence Flori and Brice Kumulungui and Christophe Aucan and Caroline Esnault and Alfred Sabab{\'e}n{\'e}djo Traor{\'e} and Francis Fumoux and Pascal Rihet},
  journal={Genes and Immunity},
  year={2003},
  volume={4},
  pages={265-268}
}
We have previously mapped a locus controlling Plasmodium falciparum blood infection levels (PFBI) to chromosome 5q31–q33. We genotyped 19 microsatellite markers on chromosome 5q31–q33 in a new sample of 44 pedigrees comprising 84 nuclear families and 292 individuals living in a P. falciparum endemic area. Using a nonparametric multipoint variance-component approach (by GENEHUNTER), we evidenced a peak of linkage close to D5S636 (P=0.0069), with a heritability of 0.46. Using a variance-component… CONTINUE READING

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IgG subclass responses against RESA and MSP2 of Plasmodium falciparum in adults in Papua New Guinea

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